RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an subterranean weapons facility in Syria used by the IS group, according to the UK's MoD.
The site, identified by reconnaissance, was thought to be storing arms and explosives, the release indicated, and was situated in mountainous terrain just north of the ancient city of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to strike a number of access tunnels leading to the depot... initial indications are that the strike was effective," the MoD said.
There was no evidence of any civilian impact in the strike on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager refuelling tanker.
Daesh - referred to as Daesh - imposed militant control over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates British leadership, and resolve to stand shoulder to shoulder with our allies, to eliminate any re-emergence of the terrorist group and their violent and radical beliefs in the region," Britain's Defence Chief the minister said.
RAF aircraft have conducted surveillance missions over Syrian airspace to "prevent any attempted comeback" of Islamic State following its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank every member of our armed forces participating in this mission for their skill and their bravery," Healey added. "They were among a great many UK service members on duty over Christmas and New Year. This mission, to eliminate militants who threaten our security, demonstrates how our armed forces are ready to step up, continuously, keeping Britain secure within its borders and influential overseas."
In December, the American forces carried out what it described as a "massive strike" against Daesh sites in Syria, following an attack killed two US troops and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still maintains an estimated 5,000 to 7,000 fighters in Syria and Iraq.
